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Article

Differential expression of α-synuclein splice variants in the brain of alcohol misusers: Influence of genotype.

Drug and alcohol dependence - 1 Oct 2015

Janeczek Paulina, Brooker Corinne, Dodd Peter R, Lewohl Joanne M

Abstract excerpt

BACKGROUND: Chronic alcohol misuse causes damage in the central nervous system that may lead to tolerance, craving and dependence. These behavioural changes are likely the result of cellular adaptations that include changes in gene expression. α-Synuclein is involved in the dopaminergic reward pathway, where it regulates dopamine synthesis and release. Previous studies have found that the gene for α-synuclein,...

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Source

Identifiers

PMID: 26297298
DOI: 10.1016/j.drugalcdep.2015.05.045

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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