Article
Association of alcohol craving with alpha-synuclein (SNCA).
Alcoholism, clinical and experimental research - 1 Apr 2007
Foroud Tatiana, Wetherill Leah Flury, Liang Tiebing, Dick Danielle M, Hesselbrock Victor, Kramer John, Nurnberger John, Schuckit Marc, Carr Lucinda, Porjesz Bernice, Xuei Xiaoling, Edenberg Howard J
Abstract excerpt
BACKGROUND: Studies have found that genomic variation in the gene SNCA, which encodes the protein alpha-synuclein, may contribute to the variation in alcohol consumption in an inbred rat model of alcohol preference. Studies in humans have provided support for an association between SNCA and craving for alcohol. METHODS: To examine the role of this gene in alcohol dependence and related phenotypes, 30 single...
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