Article
Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms.
Neuroscience letters - 6 Mar 2014
Cardo Lucía F, Coto Eliecer, de Mena Lorena, Ribacoba René, Mata Ignacio F, Menéndez Manuel, Moris Germán, Alvarez Victoria
Abstract excerpt
Mutations in the alpha-synuclein (SNCA) gene cause autosomal dominant Parkinson's disease (PD). Common SNCA polymorphisms have been associated with the risk of developing PD. Abnormal expression and post-translational modification of SNCA has been found in PD-brains. In addition to a full length transcript (SNCA-140) there are three short isoforms (SNCA-98, -112, and -126) that could be prone to aggregation. The...
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