Article
Genetic variation in the alpha synuclein gene (SNCA) is associated with BOLD response to alcohol cues.
Journal of studies on alcohol and drugs - 1 Mar 2013
Wilcox Claire E, Claus Eric D, Blaine Sara K, Morgan Marilee, Hutchison Kent E
Abstract excerpt
OBJECTIVE: Preclinical studies implicate the gene encoding the alpha synuclein protein (SNCA) in the pathophysiology of alcohol dependence and dopamine neuron function. Results from clinical studies are less conclusive. Using neurobiological phenotypes in genetic studies, rather than typical heterogeneous diagnostic categories derived from self-report, may improve reliability across studies. This study aimed to...
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