GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.

doi:10.1002/mds.26359

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Article

GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2016

Mata Ignacio F, Leverenz James B, Weintraub Daniel, Trojanowski John Q, Chen-Plotkin Alice, Van Deerlin Vivianna M, Ritz Beate, Rausch Rebecca, Factor Stewart A, Wood-Siverio Cathy, Quinn Joseph F, Chung Kathryn A, Peterson-Hiller Amie L, Goldman Jennifer G, Stebbins Glenn T, Bernard Bryan, Espay Alberto J, Revilla Fredy J, Devoto Johnna, Rosenthal Liana S, Dawson Ted M, Albert Marilyn S, Tsuang Debby, Huston Haley, Yearout Dora, Hu Shu-Ching, Cholerton Brenna A, Montine Thomas J, Edwards Karen L, Zabetian Cyrus P

Abstract excerpt

BACKGROUND: Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known. METHODS: We screened the GBA coding region for mutations and the E326K polymorphism in 1,369 PD patients enrolled at eight sites from the PD Cognitive...

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Identifiers

PMID: 26296077
DOI: 10.1002/mds.26359
PMCID: PMC4724255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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