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Article

The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal.

Neuroscience letters - 29 Sept 2017

Berge-Seidl Victoria, Pihlstrøm Lasse, Maple-Grødem Jodi, Forsgren Lars, Linder Jan, Larsen Jan Petter, Tysnes Ole-Bjørn, Toft Mathias

Abstract excerpt

OBJECTIVE: Coding variants in the GBA gene have been identified as the numerically most important genetic risk factors for Parkinson's disease (PD). In addition, genome-wide association studies (GWAS) have identified associations with PD in the SYT11-GBA region on chromosome 1q22, but the relationship to GBA coding variants have remained unclear. The aim of this study was to sequence the complete GBA gene in a...

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Source

Identifiers

PMID: 28830825
DOI: 10.1016/j.neulet.2017.08.040

Genes

SYT11

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