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Article

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Biochemical pharmacology - 1 Aug 2016

Zhang Yihong, Colenso Charlotte K, El Harchi Aziza, Cheng Hongwei, Witchel Harry J, Dempsey Chris E, Hancox Jules C

Abstract excerpt

The antiarrhythmic drug amiodarone delays cardiac repolarisation through inhibition of hERG-encoded potassium channels responsible for the rapid delayed rectifier potassium current (IKr). This study aimed to elucidate molecular determinants of amiodarone binding to the hERG channel. Whole-cell patch-clamp recordings were made at 37°C of ionic current (IhERG) carried by wild-type (WT) or mutant hERG channels...

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Identifiers

PMID: 27256139
DOI: 10.1016/j.bcp.2016.05.013
PMCID: PMC4959829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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