Article
The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.
Genes and immunity - 1 Oct 2015
Chiaroni-Clarke R C, Li Y R, Munro J E, Chavez R A, Scurrah K J, Pezic A, Akikusa J D, Allen R C, Piper S E, Becker M L, Thompson S D, Lie B A, Flato B, Forre O, Punaro M, Wise C, Saffery R, Finkel T H, Hakonarson H, Ponsonby A-L, Ellis J A
Abstract excerpt
A preponderance of females develop autoimmune disease, including juvenile idiopathic arthritis (JIA), yet the reason for this bias remains elusive. Evidence suggests that genetic risk of disease may be influenced by sex. PTPN22 rs2476601 is associated with JIA and numerous other autoimmune diseases, and has been reported to show female-specific association with type 1 diabetes. We performed main effect and...
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