Article
Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.
The Journal of steroid biochemistry and molecular biology - 1 Jan 2015
Ellis Justine A, Scurrah Katrina J, Li Yun R, Ponsonby Anne-Louise, Chavez Raul A, Pezic Angela, Dwyer Terence, Akikusa Jonathan D, Allen Roger C, Becker Mara L, Thompson Susan D, Lie Benedicte A, Flatø Berit, Førre Oystein, Punaro Marilynn, Wise Carol, Finkel Terri H, Hakonarson Hakon, Munro Jane E
Abstract excerpt
Juvenile idiopathic arthritis (JIA) is a leading cause of childhood-onset disability. Although epistasis (gene-gene interaction) is frequently cited as an important component of heritability in complex diseases such as JIA, there is little compelling evidence that demonstrates such interaction. PTPN2, a vitamin D responsive gene, is a confirmed susceptibility gene in JIA, and PTPN2 has been suggested to interact...
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