STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.

doi:10.1371/journal.pone.0117389

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Article

STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.

PloS one - 1 Jan 2015

Fan Zhi-Dan, Wang Fei-Fei, Huang Hui, Huang Na, Ma Hui-Hui, Guo Yi-Hong, Zhang Ya-Yuan, Qian Xiao-Qing, Yu Hai-Guo

Abstract excerpt

Juvenile idiopathic arthritis (JIA) is a common autoimmune disease characterized by environmental influences along with several predisposing genes in the pathogenesis. The protein tyrosine phosphatase nonreceptor 22 (PTPN22) and signal transducer and activator of transcription factor 4 (STAT4) have been recognized as susceptibility genes for numerous autoimmune diseases. Associations of STAT4 rs7574865 G/T and...

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Identifiers

PMID: 25781893
DOI: 10.1371/journal.pone.0117389
PMCID: PMC4363145

Genes

PTPN22
STAT4

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