Article
The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Sept 2017
López-Cano Daniela Josabeth, Cadena-Sandoval Daniel, Beltrán-Ramírez Olga, Barbosa-Cobos Rosa Elda, Sánchez-Muñoz Fausto, Amezcua-Guerra Luis Manuel, Juárez-Vicuña Yaneli, Aguilera-Cartas María Concepción, Moreno José, Bautista-Olvera Jesús, Valencia-Pacheco Guillermo, López-Villanueva Ricardo F, Ramírez-Bello Julian
Abstract excerpt
OBJECTIVE: The functional PTPN22 R620W polymorphism (rs2476601) is clearly associated with susceptibility to several autoimmune diseases (ADs). However, the PTPN22 R263Q polymorphism (rs33996649) has been scarcely explored in different ADs. Here we aimed to examine the associations of the PTPN22 R620W and R263Q polymorphisms with susceptibility to or protection against rheumatoid arthritis (RA), systemic lupus...
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