Article
Association between the Thr325Ile polymorphism of the thrombin-activatable fibrinolysis inhibitor and stroke in the Ludwigshafen Risk and Cardiovascular Health Study.
Thrombosis and haemostasis - 1 May 2010
Kozian Detlef H, Lorenz Martin, März Winfried, Cousin Emmanuelle, Mace Sandrine, Deleuze Jean-Francois
Abstract excerpt
The thrombin-activatable fibrinolysis inhibitor (TAFI) is a key mediator in the regulation of endogenous fibrinolysis, down-regulating clot lysis by degrading the C-terminal lysine residues from fibrin, which are important for binding and activating plasminogen. Elevated TAFI antigen levels have been suggested to be associated with promoter variants and the Ala147Thr polymorphism; increased TAFI stability and...
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