Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice.

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Article

Variable phenotypic expressivity in inbred retinal degeneration mouse lines: A comparative study of C3H/HeOu and FVB/N rd1 mice.

Molecular vision - 1 Jan 2015

van Wyk Michiel, Schneider Sabine, Kleinlogel Sonja

Abstract excerpt

PURPOSE: Recent advances in optogenetics and gene therapy have led to promising new treatment strategies for blindness caused by retinal photoreceptor loss. Preclinical studies often rely on the retinal degeneration 1 (rd1 or Pde6b(rd1)) retinitis pigmentosa (RP) mouse model. The rd1 founder mutation is present in more than 100 actively used mouse lines. Since secondary genetic traits are well-known to modify the...

Topics

Animals
Cyclic Nucleotide Phosphodiesterases, Type 6
Disease Progression
Electroretinography
Female
Humans
Male
Mice
Mice, Congenic
Mice, Inbred C3H
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Mutant Proteins

Opsins

Optogenetics

Phenotype

RNA, Messenger

Retinal Degeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 26283863
PMCID: PMC4522243

Genes

Provenance

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