Article
Review: the history and role of naturally occurring mouse models with Pde6b mutations.
Molecular vision - 20 Dec 2013
Han Juanjuan, Dinculescu Astra, Dai Xufeng, Du Wei, Smith W Clay, Pang Jijing
Abstract excerpt
Mouse models are useful tools for developing potential therapies for human inherited retinal diseases, such as retinitis pigmentosa (RP), since more strains are being identified with the same mutant genes and phenotypes as humans with corresponding retinal degenerative diseases. Mutations in the beta subunit of the human rod phosphodiesterase (PDE6B) gene are a common cause of autosomal recessive RP (arRP). This...
Topics
- Adenoviridae
- Animals
- Cell- and Tissue-Based Therapy
- Cyclic Nucleotide Phosphodiesterases, Type 6
- Disease Models, Animal
- Gene Expression
- Genetic Therapy
- Genetic Vectors
- Humans
- Mice
- Mutation
- Retina
- Retinitis Pigmentosa