Article
Genetic variations strongly influence phenotypic outcome in the mouse retina.
PloS one - 1 Jan 2011
Jelcick Austin S, Yuan Yang, Leehy Barrett D, Cox Lakeisha C, Silveira Alexandra C, Qiu Fang, Schenk Sarah, Sachs Andrew J, Morrison Margaux A, Nystuen Arne M, DeAngelis Margaret M, Haider Neena B
Abstract excerpt
Variation in genetic background can significantly influence the phenotypic outcome of both disease and non-disease associated traits. Additionally, differences in temporal and strain specific gene expression can also contribute to phenotypes in the mammalian retina. This is the first report of microarray based cross-strain analysis of gene expression in the retina investigating genetic background effects....
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