A congenic C57BL/6J rd1 mouse model for retinal degeneration research.

Abstract excerpt

Retinitis pigmentosa is an inherited retinal disease caused by thousands of mutations in over 100 different genes. The most widely used mouse model for retinitis pigmentosa has the retinal degeneration 1 (rd1) mutation in the Pde6b gene, which elicits rapid retinal degeneration and vision loss. A major limitation of these models is that these rd1 strains are not congenic, which prevents the use of appropriate...

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