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Article

Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds.

Investigative ophthalmology & visual science - 1 Feb 2010

Brunner Sandra, Skosyrski Sergej, Kirschner-Schwabe Renate, Knobeloch Klaus-Peter, Neidhardt John, Feil Silke, Glaus Esther, Luhmann Ulrich F O, Rüther Klaus, Berger Wolfgang

Abstract excerpt

PURPOSE: To establish mouse models for RPGR-associated diseases by generating and characterizing an Rpgr mutation (in-frame deletion of exon 4) in two different genetic backgrounds (BL/6 and BALB/c). METHODS: Gene targeting in embryonic stem (ES) cells was performed to introduce a in-frame deletion of exon 4 in the Rpgr gene (Rpgr(DeltaEx4)). Subsequently, the mutation was introduced in two different inbred mouse...

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Identifiers

PMID: 20007830
DOI: 10.1167/iovs.08-2742

Genes

RPGR
ERG
RPGRIP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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