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Article

piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals

17 Aug 2015

Abstract excerpt

Endogenous bornavirus-like nucleoprotein elements (EBLNs) are sequences within vertebrate genomes derived from reverse transcription and integration of ancient bornaviral nucleoprotein mRNA via the host retrotransposon machinery. While species with EBLNs appear relatively resistant to bornaviral disease, the nature of this association is unclear. We hypothesized that EBLNs could give rise to antiviral interfering...

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PMID: 26283688
DOI: 10.1261/rna.052092.115

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