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Article

Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis.

Antimicrobial agents and chemotherapy - 1 Nov 2015

Rawson Jonathan M O, Landman Sean R, Reilly Cavan S, Bonnac Laurent, Patterson Steven E, Mansky Louis M

Abstract excerpt

Decitabine has previously been shown to induce lethal mutagenesis of human immunodeficiency virus type 1 (HIV-1). However, the factors that determine the susceptibilities of individual sequence positions in HIV-1 to decitabine have not yet been defined. To investigate this, we performed Illumina high-throughput sequencing of multiple amplicons prepared from proviral DNA that was recovered from decitabine-treated...

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Identifiers

PMID: 26282416
DOI: 10.1128/AAC.01644-15
PMCID: PMC4604356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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