Article
Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461.
PloS one - 14 Jan 2011
Mullins James I, Heath Laura, Hughes James P, Kicha Jessica, Styrchak Sheila, Wong Kim G, Rao Ushnal, Hansen Alexis, Harris Kevin S, Laurent Jean-Pierre, Li Deyu, Simpson Jeffrey H, Essigmann John M, Loeb Lawrence A, Parkins Jeffrey
Abstract excerpt
The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infected volunteers from the first "mechanism validation" phase II clinical trial of a mutagenic base analog in which...
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