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Article

Back to the future: revisiting HIV-1 lethal mutagenesis.

Trends in microbiology - 1 Feb 2013

Dapp Michael J, Patterson Steven E, Mansky Louis M

Abstract excerpt

The concept of eliminating HIV-1 infectivity by elevating the viral mutation rate was first proposed over a decade ago, even though the general concept had been conceived earlier for RNA viruses. Lethal mutagenesis was originally viewed as a novel chemotherapeutic approach for treating HIV-1 infection in which use of a viral mutagen would over multiple rounds of replication lead to the lethal accumulation of...

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Identifiers

PMID: 23195922
DOI: 10.1016/j.tim.2012.10.006
PMCID: PMC3565075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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