Article
Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2015
Wang Jiarong, Bao Lei, Yu Benli, Liu Zhaoyun, Han Wenli, Deng Chun, Guo Chunbao
Abstract excerpt
BACKGROUND/AIMS: IL-1β creates persistent pulmonary inflammation accompanied by elevated transforming growth factor β (TGF-β levels and is associated with abnormal elastogenesis, which is observed in bronchopulmonary dysplasia (BPD). Although progress has been made in this field, the mechanisms underlying this process remain only partially understood. METHODS: We assessed aberrant elastin localization-associated...
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