Article

TGFβ controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription

2023-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Premature birth disrupts normal lung development and places infants at risk for bronchopulmonary dysplasia (BPD), a disease increasing in incidence which disrupts lung health throughout the lifespan. The TGFβ superfamily has been implicated in BPD pathogenesis, however, what cell lineage it impacts remains unclear. We show that Tgfbr2 is critical for AT1 cell fate maintenance and function. Loss...

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Literature Corpus work: e9d945a1-cf73-5511-b64a-dfd05496cfd4
DOI: 10.1101/2023.05.09.540035

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