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Article

Transforming Growth Factor-β Signaling across Ages: From Distorted Lung Development to Chronic Obstructive Pulmonary Disease

24 Nov 2009

Abstract excerpt

The transforming growth factor (TGF)-beta superfamily of secreted growth factors consists of more than 40 members, including the TGF-beta isoforms themselves, bone morphogenetic proteins, and activins. Most of these factors have been shown to be essential for proper organ development, a process often recapitulated in chronic diseases. Importantly, TGF-beta superfamily members are key regulators of extracellular...

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PMID: 19934357
DOI: 10.1513/pats.200908-087rm

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