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Article

Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease

20 Mar 2024

Abstract excerpt

Alveolarization ensures sufficient lung surface area for gas exchange, and during bulk alveolarization in mice (postnatal day [P] 4.5–14.5), alpha-smooth muscle actin (SMA) + myofibroblasts accumulate, secrete elastin, and lay down alveolar septum. Herein, we delineate the dynamics of the lineage of early postnatal SMA + myofibroblasts during and after bulk alveolarization and in response to lung injury. SMA +...

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PMID: 38572485
DOI: 10.3389/fcell.2024.1335061

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