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Article

Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.

Scientific reports - 16 Oct 2017

Ayaub Ehab A, Dubey Anisha, Imani Jewel, Botelho Fernando, Kolb Martin R J, Richards Carl D, Ask Kjetil

Abstract excerpt

Although recent evidence indicates that gp130 cytokines, Oncostatin M (OSM) and IL-6 are involved in alternative programming of macrophages, their role in lung fibrogenesis is poorly understood. Here, we investigated the effect of transient adenoviral overexpression of OSM or IL-6 in mice during bleomycin-induced lung fibrosis. Lung fibrosis and M2-like macrophage accumulation were assessed by...

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Source

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Identifiers

PMID: 29038604
DOI: 10.1038/s41598-017-13511-z
PMCID: PMC5643520

Genes

OSM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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