Article
Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung.
Respiratory research - 16 Jan 2015
Sureshbabu Angara, Syed Mansoor A, Boddupalli Chandra Sekhar, Dhodapkar Madhav V, Homer Robert J, Minoo Parviz, Bhandari Vineet
Abstract excerpt
BACKGROUND: Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a pulmonary phenotype of bronchopulmonary dysplasia (BPD). However, the mechanisms responsible for the TGFβ1-induced inflammatory signals that lead to cell death and abnormal alveolarization are...
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