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Article

Genotyping concordance in DNA extracted from formalin-fixed paraffin embedded (FFPE) breast tumor and whole blood for pharmacogenetic analyses.

Molecular oncology - 1 Nov 2015

Hertz Daniel L, Kidwell Kelley M, Thibert Jacklyn N, Gersch Christina, Regan Meredith M, Skaar Todd C, Henry N Lynn, Hayes Daniel F, Van Poznak Catherine H, Rae James M

Abstract excerpt

BACKGROUND: Cancer pharmacogenetic studies use archival tumor samples as a DNA source when germline DNA is unavailable. Genotyping DNA from formalin-fixed paraffin embedded tumors (FFPE-T) may be inaccurate due to FFPE storage, genetic aberrations, and/or insufficient DNA extraction. Our objective was to assess the extent and source of genotyping inaccuracy from FFPE-T DNA and demonstrate analytical validity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26276228
DOI: 10.1016/j.molonc.2015.07.002
PMCID: PMC4624024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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