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Article

Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.

Journal of the National Cancer Institute - 4 Sept 2013

Rae James M, Regan Meredith M, Thibert Jacklyn N, Gersch Christina, Thomas Dafydd, Leyland-Jones Brian, Viale Giuseppe, Pusztai Lajos, Hayes Daniel F, Skaar Todd, Van Poznak Catherine

Abstract excerpt

Formalin-fixed, paraffin-embedded tumors (FFPETs) are a valuable source of DNA for genotype association studies and are often the only germline DNA resource from cancer clinical trials. The anti-estrogen tamoxifen is metabolized into endoxifen by CYP2D6, leading to the hypothesis that patients with certain CYP2D6 genotypes may not receive benefit because of their inability to activate the drug. Studies testing...

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Identifiers

PMID: 23958736
DOI: 10.1093/jnci/djt204
PMCID: PMC3888280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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