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Article

Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.

Journal of the National Cancer Institute - 4 Sept 2013

Rae James M, Regan Meredith M, Thibert Jacklyn N, Gersch Christina, Thomas Dafydd, Leyland-Jones Brian, Viale Giuseppe, Pusztai Lajos, Hayes Daniel F, Skaar Todd, Van Poznak Catherine

Abstract excerpt

Formalin-fixed, paraffin-embedded tumors (FFPETs) are a valuable source of DNA for genotype association studies and are often the only germline DNA resource from cancer clinical trials. The anti-estrogen tamoxifen is metabolized into endoxifen by CYP2D6, leading to the hypothesis that patients wi...

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Identifiers

PMID: 23958736
DOI: 10.1093/jnci/djt204
PMCID: PMC3888280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23958736-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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