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Article

Assessing the suitability of formalin-fixed paraffin-embedded (FFPE) tissue for genome-wide association studies (GWAS).

BMC research notes - 1 Jul 2025

Reingruber Julian, Krämer Maximilian J, Bigge Jessica, Dasmeh Pouria, Grover Sandeep, Heilmann-Heimbach Stefanie, Nöthen Markus M, Kreuser Nicole, Gockel Ines, Veits Lothar, Vieth Michael, Jank Paul, Denkert Carsten, Maj Carlo, Hess Timo, Schumacher Johannes

Abstract excerpt

OBJECTIVE: The power of genome-wide association studies (GWAS) to identify common disease variants depends primarily on the number of included samples. The availability of formalin-fixed paraffin-embedded (FFPE) samples in pathology institutes provides a valuable resource for GWAS, but the use of this material poses significant challenges. To explore the suitability of utilizing FFPE tissue for GWAS, we analysed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40598669
DOI: 10.1186/s13104-025-07306-z
PMCID: PMC12211376

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