Article
Morc1 knockout evokes a depression-like phenotype in mice.
Behavioural brain research - 1 Jan 2016
Schmidt M, Brandwein C, Luoni A, Sandrini P, Calzoni T, Deuschle M, Cirulli F, Riva M A, Gass P
Abstract excerpt
Morc1 gene has recently been identified by a DNA methylation and genome-wide association study as a candidate gene for major depressive disorder related to early life stress in rodents, primates and humans. So far, no transgenic animal model has been established to validate these findings on a behavioral level. In the present study, we examined the effects of a Morc1 loss of function mutation in female C57BL/6N...
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