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Article

A next-generation sequencing study on mechanisms by which restraint and social instability stresses of male mice alter offspring anxiety-like behavior.

Scientific reports - 12 Apr 2021

Kong Qiao-Qiao, Tian Xiao-Dan, Wang Jia, Yuan Hong-Jie, Ning Shu-Fen, Luo Ming-Jiu, Tan Jing-He

Abstract excerpt

Pathophysiological mechanisms for depression/anxiety are largely unknown. Evidence for transgenerational transmission of acquired epigenetic marks remains limited. We bred unstressed (US) female mice with adolescently restraint-stressed (RS), social instability-stressed (SI) or US males to produce RS, SI and control F1 offspring, respectively. Compared to controls, while paternal RS decreased anxiety-like...

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Identifiers

PMID: 33846458
DOI: 10.1038/s41598-021-87060-x
PMCID: PMC8042048

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