Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2011

Zubenko George S, Hughes Hugh B

Abstract excerpt

Major depressive disorder (MDD) is a leading cause of disability worldwide. Families with recurrent, early-onset MDD (RE-MDD), a severe, familial form of MDD, have provided an important resource for identifying and characterizing genetic variants that confer susceptibility to MDD and related disorders. Previous studies identified a rare, highly penetrant A(-115)G transition within the human CREB1 promoter that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cyclic AMP Response Element-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Disease Models, Animal

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Promoter Regions, Genetic

Share to Sequence Homology

Source

Open in PubMed Open full text

Identifiers

PMID: 21598377
DOI: 10.1002/ajmg.b.31197
PMCID: PMC3236563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder.PMID 21598377Read ↗

Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.Semantic proximity Read ↗

Alterations of brain anatomy in mouse model of MDD created by replacement of homologous mouse DNA sequence with an illness-associated 6-base human CREB1 promoter sequence.Semantic proximity Read ↗

Sequence variations in CREB1 cosegregate with depressive disorders in women.Semantic proximity Read ↗

Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress.Semantic proximity Read ↗

Translating the evidence for gene association with depression into mouse models of depression-relevant behaviour: current limitations and future potential.Semantic proximity Read ↗

Genomic variants in an inbred mouse model predict mania-like behaviors.Semantic proximity Read ↗

Effects of the G(-656)A variant on CREB1 promoter activity in a glial cell line: interactions with gonadal steroids and stress.Semantic proximity Read ↗

Sex Significantly Impacts the Function of Major Depression-Linked Variants In Vivo.Semantic proximity Read ↗

A new mouse model for mania shares genetic correlates with human bipolar disorder.Semantic proximity Read ↗

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers predictive of treatment responseSemantic proximity Read ↗

Genetic linkage of region containing the <i>CREB1</i> gene to depressive disorders in women from families with recurrent, early‐onset, major depressionSemantic proximity Read ↗

Sex significantly impacts the function of major depression-linked variants <i>in vivo</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.