Article
Assessing the prediction fidelity of ancestral reconstruction by a library approach.
Protein engineering, design & selection : PEDS - 1 Nov 2015
Bar-Rogovsky Hagit, Stern Adi, Penn Osnat, Kobl Iris, Pupko Tal, Tawfik Dan S
Abstract excerpt
Ancestral reconstruction is a powerful tool for studying protein evolution as well as for protein design and engineering. However, in many positions alternative predictions with relatively high marginal probabilities exist, and thus the prediction comprises an ensemble of near-ancestor sequences that relate to the historical ancestor. The ancestral phenotype should therefore be explored for the entire ensemble,...
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