Article
Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins.
Proteins - 1 Jun 2014
Risso Valeria A, Gavira Jose A, Gaucher Eric A, Sanchez-Ruiz Jose M
Abstract excerpt
Consensus-sequence engineering has generated protein variants with enhanced stability, and sometimes, with modulated biological function. Consensus mutations are often interpreted as the introduction of ancestral amino acid residues. However, the precise relationship between consensus engineering and ancestral protein resurrection is not fully understood. Here, we report the properties of proteins encoded by...
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