Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.

Molecular biology and evolution - 1 Feb 2017

Eick Geeta N, Bridgham Jamie T, Anderson Douglas P, Harms Michael J, Thornton Joseph W

Abstract excerpt

Hypotheses about the functions of ancient proteins and the effects of historical mutations on them are often tested using ancestral protein reconstruction (APR)-phylogenetic inference of ancestral sequences followed by synthesis and experimental characterization. Usually, some sequence sites are ambiguously reconstructed, with two or more statistically plausible states. The extent to which the inferred functions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biometry
Share to DNA, Ancient
Share to Likelihood Functions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Domains

Share to Proteins

Share to Sequence Alignment

Share to Structure-Activity Relationship

Share to Uncertainty

Source

Open in PubMed Open full text

Identifiers

PMID: 27795231
DOI: 10.1093/molbev/msw223
PMCID: PMC6095102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.PMID 27795231Read ↗

Reconstructing Ancient Proteins to Understand the Causes of Structure and Function.Semantic proximity Read ↗

Alternative evolutionary histories in the sequence space of an ancient protein.Semantic proximity Read ↗

Assessing the prediction fidelity of ancestral reconstruction by a library approach.Semantic proximity Read ↗

Reconstruction and testing of ancestral proteins.Semantic proximity Read ↗

Impact of ancestral sequence reconstruction on mechanistic and structural enzymology.Semantic proximity Read ↗

Assessing the accuracy of ancestral protein reconstruction methods.Semantic proximity Read ↗

Characters of very ancient proteins.Semantic proximity Read ↗

Exploring the relationship between sequence similarity and accurate phylogenetic trees.Semantic proximity Read ↗

Protein dynamism and evolvability.Semantic proximity Read ↗

An experimental phylogeny to benchmark ancestral sequence reconstruction.Semantic proximity Read ↗

Evolution of the protein repertoire.Semantic proximity Read ↗

Ancient Reconstructed Proteins: A Framework for Resurrecting Protein Structures from Million-Year-Old MetagenomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.