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Article

Impact of ancestral sequence reconstruction on mechanistic and structural enzymology.

Current opinion in structural biology - 1 Oct 2023

Nicoll Callum R, Massari Marta, Fraaije Marco W, Mascotti Maria Laura, Mattevi Andrea

Abstract excerpt

Ancestral sequence reconstruction (ASR) provides insight into the changes within a protein sequence across evolution. More specifically, it can illustrate how specific amino acid changes give rise to different phenotypes within a protein family. Over the last few decades it has established itself as a powerful technique for revealing molecular common denominators that govern enzyme function. Here, we describe the...

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PMID: 37544113
DOI: 10.1016/j.sbi.2023.102669

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