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Article

Evolution of Enzyme Superfamilies: Comprehensive Exploration of Sequence-Function Relationships.

Biochemistry - 22 Nov 2016

Baier F, Copp J N, Tokuriki N

Abstract excerpt

The sequence and functional diversity of enzyme superfamilies have expanded through billions of years of evolution from a common ancestor. Understanding how protein sequence and functional "space" have expanded, at both the evolutionary and molecular level, is central to biochemistry, molecular biology, and evolutionary biology. Integrative approaches that examine protein sequence, structure, and function have...

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Identifiers

PMID: 27802036
DOI: 10.1021/acs.biochem.6b00723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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