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Article

N-terminal-mediated oligomerization of DnaA drives the occupancy-dependent rejuvenation of the protein on the membrane.

Bioscience reports - 13 Aug 2015

Aranovich Alexander, Braier-Marcovitz Shani, Ansbacher Esti, Granek Rony, Parola Abraham H, Fishov Itzhak

Abstract excerpt

DnaA, the initiator of chromosome replication in most known eubacteria species, is activated once per cell division cycle. Its overall activity cycle is driven by ATP hydrolysis and ADP-ATP exchange. The latter can be promoted by binding to specific sequences on the chromosome and/or to acidic phospholipids in the membrane. We have previously shown that the transition into an active form (rejuvenation) is...

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Identifiers

PMID: 26272946
DOI: 10.1042/BSR20150175
PMCID: PMC4721551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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