Article
A Eukaryotic Sensor for Membrane Lipid Saturation.
Molecular cell - 7 Jul 2016
Covino Roberto, Ballweg Stephanie, Stordeur Claudius, Michaelis Jonas B, Puth Kristina, Wernig Florian, Bahrami Amir, Ernst Andreas M, Hummer Gerhard, Ernst Robert
Abstract excerpt
Maintaining a fluid bilayer is essential for cell signaling and survival. Lipid saturation is a key factor determining lipid packing and membrane fluidity, and it must be tightly controlled to guarantee organelle function and identity. A dedicated eukaryotic mechanism of lipid saturation sensing, however, remains elusive. Here we show that Mga2, a transcription factor conserved among fungi, acts as a...
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