Article
Review: High-performance computing to detect epistasis in genome scale data sets.
Briefings in bioinformatics - 1 May 2016
Upton Alex, Trelles Oswaldo, Cornejo-García José Antonio, Perkins James Richard
Abstract excerpt
It is becoming clear that most human diseases have a complex etiology that cannot be explained by single nucleotide polymorphisms (SNPs) or simple additive combinations; the general consensus is that they are caused by combinations of multiple genetic variations. The limited success of some genome-wide association studies is partly a result of this focus on single genetic markers. A more promising approach is to...
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