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Article

High-throughput analysis of epistasis in genome-wide association studies with BiForce.

Bioinformatics (Oxford, England) - 1 Aug 2012

Gyenesei Attila, Moody Jonathan, Semple Colin A M, Haley Chris S, Wei Wen-Hua

Abstract excerpt

MOTIVATION: Gene-gene interactions (epistasis) are thought to be important in shaping complex traits, but they have been under-explored in genome-wide association studies (GWAS) due to the computational challenge of enumerating billions of single nucleotide polymorphism (SNP) combinations. Fast screening tools are needed to make epistasis analysis routinely available in GWAS. RESULTS: We present BiForce to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22618535
DOI: 10.1093/bioinformatics/bts304
PMCID: PMC3400955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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