Article
Deficiency of mannose-binding lectin is a risk of Pneumocystis jirovecii pneumonia in a natural history cohort of people living with HIV/AIDS in Northern Thailand.
PloS one - 1 Jan 2020
Yanagisawa Kunio, Wichukchinda Nuanjun, Tsuchiya Naho, Yasunami Michio, Rojanawiwat Archawin, Tanaka Hidenori, Saji Hiroh, Ogawa Yoshiyuki, Handa Hiroshi, Pathipvanich Panita, Ariyoshi Koya, Sawanpanyalert Pathom
Abstract excerpt
BACKGROUND: Mannose-binding lectin (MBL) plays a pivotal role in innate immunity; however, its impact on susceptibility to opportunistic infections (OIs) has not yet been examined in a natural history cohort of people living with HIV/AIDS. METHODS: We used archived samples to analyze the association between MBL expression types and risk of major OIs including Pneumocystis jirovecii pneumonia (PCP),...
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