Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against <i>Trypanosoma brucei</i>

13 Aug 2015

Abstract excerpt

Marine natural products are an important source of lead compounds against many pathogenic targets. Herein, we report the discovery of lobosamides A-C from a marine actinobacterium, Micromonospora sp., representing three new members of a small but growing family of bacterially produced polyene macrolactams. The lobosamides display growth inhibitory activity against the protozoan parasite Trypanosoma brucei...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbohydrate Chemistry and Synthesis
Share to Microbial Natural Products and Biosynthesis
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26270237
DOI: 10.1021/acschembio.5b00308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against <i>Trypanosoma brucei</i>PMID 26270237Read ↗

Identification of the 216kbp gene cluster and structure elucidation of gargantulides B and C, new complex 52-membered macrolides from <i>Amycolatopsis</i> spSemantic proximity Read ↗

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in <i>Streptomyces ambofaciens</i>Semantic proximity Read ↗

Uncovering Lasonolide A biosynthesis using genome-resolved metagenomicsSemantic proximity Read ↗

Mining Symbionts of a Spider‐Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic BenzolactonesSemantic proximity Read ↗

<i>In situ</i> activation and heterologous production of a cryptic lantibiotic from a plant-ant derived <i>Saccharopolyspora</i> speciesSemantic proximity Read ↗

Antarmycins: Discovery, Biosynthesis, Anti-pathogenic Bacterial Activity, and Mechanism of Action from Deep-Sea-Derived Pseudonocardia antarcticaSemantic proximity Read ↗

Structure elucidation and antitumour activity of a new macrolactam produced by marine-derived actinomycete <i>Micromonospora</i> sp. FIM05328Semantic proximity Read ↗

Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug DiscoverySemantic proximity Read ↗

Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.Semantic proximity Read ↗

Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Polycyclic Tetramate Macrolactams—A Group of Natural Bioactive MetallophoresSemantic proximity Read ↗

Complete Characterization of the Seventeen Step Moenomycin Biosynthetic PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.