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Article

Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2010

Blodgett Joshua A V, Oh Dong-Chan, Cao Shugeng, Currie Cameron R, Kolter Roberto, Clardy Jon

Abstract excerpt

A combination of small molecule chemistry, biosynthetic analysis, and genome mining has revealed the unexpected conservation of polycyclic tetramate macrolactam biosynthetic loci in diverse bacteria. Initially our chemical analysis of a Streptomyces strain associated with the southern pine beetle led to the discovery of frontalamides A and B, two previously undescribed members of this antibiotic family. Genome...

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Identifiers

PMID: 20547882
DOI: 10.1073/pnas.1001513107
PMCID: PMC2900643

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