Article

Uncovering Lasonolide A biosynthesis using genome-resolved metagenomics

2022-05-23

Abstract excerpt

Invertebrates, in particular sponges, have been a dominant source of new marine natural products. For example, lasonolide A (LSA) is a potential anti-cancer molecule isolated from the marine sponge Forcepia sp., with nanomolar growth inhibitory activity and a unique cytotoxicity profile against the National Cancer Institute 60 cell line screen. Here, we identified the putative biosynthetic pathway for LSA. Genomi...

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Literature Corpus work: a087653c-7abe-5546-b646-0abffb72e963
DOI: 10.1101/2022.05.23.493085

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