Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway.

doi:10.1042/BST20211288

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Article

Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway.

Biochemical Society transactions - 28 Feb 2022

Albanese Federica, Domenicale Chiara, Volta Mattia, Morari Michele

Abstract excerpt

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson's disease (PD), for which the LRRK2 locus itself represents a risk factor. Idiopathic and LRRK2-related PD share the main clinical and neuropathological features, thus animals h...

Topics

Animals
Autophagy
Dopaminergic Neurons
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Lysosomes
Mice
Mutation
Parkinson Disease

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