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Article

Src Continues Aging: Current and Future Clinical Directions

15 Dec 2007

Abstract excerpt

Aberrant activation of members of the Src family of nonreceptor protein tyrosine kinases is common in solid tumor malignancies and may contribute to the development and/or progression of these tumors. As a result, four Src inhibitors are now in more than 50 clinical trials for at least 14 different types of solid tumors. In this review, we briefly discuss the preclinical rationale for Src inhibitors, the...

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PMID: 18094400
DOI: 10.1158/1078-0432.ccr-07-1902

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