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Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer

22 Sept 2016

Abstract excerpt

Coactivators represent a large class of proteins that partner with nuclear receptors and other transcription factors to regulate gene expression. Given their pleiotropic roles in the control of transcription, coactivators have been implicated in a broad range of human disease states, including cancer. This is best typified by the three members of the steroid receptor coactivator (SRC) family, each of which...

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PMID: 27654711
DOI: 10.1158/1078-0432.ccr-15-1958

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