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Article

SEC14L2 enables pan-genotype HCV replication in cell culture.

Nature - 27 Aug 2015

Saeed Mohsan, Andreo Ursula, Chung Hyo-Young, Espiritu Christine, Branch Andrea D, Silva Jose M, Rice Charles M

Abstract excerpt

Since its discovery in 1989, efforts to grow clinical isolates of the hepatitis C virus (HCV) in cell culture have met with limited success. Only the JFH-1 isolate has the capacity to replicate efficiently in cultured hepatoma cells without cell culture-adaptive mutations. We hypothesized that cultured cells lack one or more factors required for the replication of clinical isolates. To identify the missing...

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Identifiers

PMID: 26266980
DOI: 10.1038/nature14899
PMCID: PMC4632207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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